Sporulosol, a New Ketal from the Fungus Paraconiothyrium sporulosum.

ABSTRACT: Sporulosol (1), a new ketal, together with four known compounds, has been isolated from the liquid fermentation cultures of a wetland-soil-derived fungus, Paraconiothyrium sporulosum. Its structure was elucidated primarily by NMR experiments, and was further confirmed by X-ray crystallography. Sporulosol was obtained as a racemic mixture and the resolved two enantiomers racemized immediately after chiral separation. Sporulosol appears to be the first ketal derived from a 6H-benzo[c]chromen-6-one and a benzofuranone unit. The compound showed modest cytotoxicity toward the human tumor cell line T24, with an IC₅₀ value of 18.2 µM.

SUBMITTER: Zhao C 

PROVIDER: S-EPMC6100215 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature