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Sporulosol, a New Ketal from the Fungus Paraconiothyrium sporulosum.


ABSTRACT: Sporulosol (1), a new ketal, together with four known compounds, has been isolated from the liquid fermentation cultures of a wetland-soil-derived fungus, Paraconiothyrium sporulosum. Its structure was elucidated primarily by NMR experiments, and was further confirmed by X-ray crystallography. Sporulosol was obtained as a racemic mixture and the resolved two enantiomers racemized immediately after chiral separation. Sporulosol appears to be the first ketal derived from a 6H-benzo[c]chromen-6-one and a benzofuranone unit. The compound showed modest cytotoxicity toward the human tumor cell line T24, with an IC50 value of 18.2 µM.

SUBMITTER: Zhao C 

PROVIDER: S-EPMC6100215 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Sporulosol, a New Ketal from the Fungus <i>Paraconiothyrium sporulosum</i>.

Zhao Chen C   Fu Peinan P   Zhang Yang Y   Liu Xingzhong X   Ren Fengxia F   Che Yongsheng Y  

Molecules (Basel, Switzerland) 20180525 6


Sporulosol (<b>1</b>), a new ketal, together with four known compounds, has been isolated from the liquid fermentation cultures of a wetland-soil-derived fungus, <i>Paraconiothyrium sporulosum</i>. Its structure was elucidated primarily by NMR experiments, and was further confirmed by X-ray crystallography. Sporulosol was obtained as a racemic mixture and the resolved two enantiomers racemized immediately after chiral separation. Sporulosol appears to be the first ketal derived from a 6<i>H</i>-  ...[more]

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