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Novel Polyketides Produced by the Endophytic Fungus Aspergillus Fumigatus from Cordyceps Sinensis.

ABSTRACT: Five new polyketides, including two pairs of enantiomers and a racemate, were isolated from the fermentation broth of Aspergillus fumigatus, an endophytic fungus isolated from Cordyceps sinensis. Their structures were identified using one-dimensional (1D) and two-dimensional (2D) NMR experiments, and the absolute configurations of the enantiomers were confirmed using electronic circular dichroism (ECD) calculations. Compounds 1a and 2a exhibited inhibitory activity against the MV4-11 cell line in vitro, with IC50 values of 23.95 µM and 32.70 µM, respectively.

SUBMITTER: Guo DL 

PROVIDER: S-EPMC6100219 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Novel Polyketides Produced by the Endophytic Fungus <i>Aspergillus Fumigatus</i> from <i>Cordyceps Sinensis</i>.

Guo Da-Le DL   Li Xiao-Hua XH   Feng Dan D   Jin Meng-Ying MY   Cao Yu-Mei YM   Cao Zhi-Xing ZX   Gu Yu-Cheng YC   Geng Zhao Z   Deng Fang F   Deng Yun Y  

Molecules (Basel, Switzerland) 20180713 7

Five new polyketides, including two pairs of enantiomers and a racemate, were isolated from the fermentation broth of <i>Aspergillus fumigatus</i>, an endophytic fungus isolated from <i>Cordyceps sinensis</i>. Their structures were identified using one-dimensional (1D) and two-dimensional (2D) NMR experiments, and the absolute configurations of the enantiomers were confirmed using electronic circular dichroism (ECD) calculations. Compounds <b>1a</b> and <b>2a</b> exhibited inhibitory activity ag  ...[more]

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