Separation of 44Sc from Natural Calcium Carbonate Targets for Synthesis of 44Sc-DOTATATE.

ABSTRACT: The rapid increase in applications of scandium isotopes in nuclear medicine requires new efficient production routes for these radioisotopes. Recently, irradiations of calcium in cyclotrons by α, deuteron, and proton beams have been used. Therefore, effective post-irradiation separation and preconcentration of the radioactive scandium from the calcium matrix are important to obtain the pure final product in a relatively small volume. Nobias resin was used as a sorbent for effective separation of 44Sc from calcium targets. Separation was performed at pH 3 using a column containing 10 mg of resin. Scandium was eluted with 100 μL of 2 mol L-1 HCl. Particular attention was paid to the reduction of calcium concentration, presence of metallic impurities, robustness and simple automation. 44Sc wa

SUBMITTER: Kilian K 

PROVIDER: S-EPMC6100303 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature