Synthesis of a Reactive Oxygen Species-Responsive Doxorubicin Derivative.

ABSTRACT: A heterobifunctional reactive oxygen species (ROS)-responsive linker for directed drug assembly onto and delivery from a quantum dot (QD) nanoparticle carrier was synthesized and coupled to doxorubicin using N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC)/sulfo⁻NHS coupling. The doxorubicin conjugate was characterized using ¹H NMR and LC-MS and subsequently reacted under conditions of ROS formation (Cu2+/H₂O₂) resulting in successful and rapid thioacetal oxidative cleavage, which was monitored using ¹H NMR.

SUBMITTER: Delehanty JB 

PROVIDER: S-EPMC6100310 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature