Phosphoproteomics of Retinoblastoma: A Pilot Study Identifies Aberrant Kinases.

ABSTRACT: Retinoblastoma is a malignant tumour of the retina which most often occurs in children. Earlier studies on retinoblastoma have concentrated on the identification of key players in the disease and have not provided information on activated/inhibited signalling pathways. The dysregulation of protein phosphorylation in cancer provides clues about the affected signalling cascades in cancer. Phosphoproteomics is an ideal tool for the study of phosphorylation changes in proteins. Hence, global phosphoproteomics of retinoblastoma (RB) was carried out to identify signalling events associated with this cancer. Over 350 proteins showed differential phosphorylation in RB compared to control retina. Our study identified stress response proteins to be hyperphosphorylated in RB which included H2A histon

SUBMITTER: Selvan LDN 

PROVIDER: S-EPMC6100359 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature