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Pyrrole Alkaloids from the Edible Mushroom Phlebopus portentosus with Their Bioactive Activities.


ABSTRACT: Seven pyrrole alkaloids, three of which are novel (phlebopines A?C (1?3)), were isolated from the fruiting bodies of the edible mushroom Phlebopus portentosus. Their structures were determined on the basis of spectroscopic data. All the isolated compounds were tested for their neuroprotective properties and acetylcholine esterase (AChE) inhibition activities. Compound 7 displayed remarkable neuroprotective effects against hydrogen peroxide (H?O?)-induced neuronal-cell damage in human neuroblastoma SH-SY5Y cells.

SUBMITTER: Sun Z 

PROVIDER: S-EPMC6100406 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Pyrrole Alkaloids from the Edible Mushroom <i>Phlebopus portentosus</i> with Their Bioactive Activities.

Sun Zhaocui Z   Hu Meigeng M   Sun Zhonghao Z   Zhu Nailiang N   Yang Junshan J   Ma Guoxu G   Xu Xudong X  

Molecules (Basel, Switzerland) 20180517 5


Seven pyrrole alkaloids, three of which are novel (phlebopines A⁻C (<b>1</b>⁻<b>3</b>)), were isolated from the fruiting bodies of the edible mushroom <i>Phlebopus portentosus</i>. Their structures were determined on the basis of spectroscopic data. All the isolated compounds were tested for their neuroprotective properties and acetylcholine esterase (AChE) inhibition activities. Compound <b>7</b> displayed remarkable neuroprotective effects against hydrogen peroxide (H₂O₂)-induced neuronal-cell  ...[more]

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