Synthesis and Activity against Mycobacterium tuberculosis of Olivacine and Oxygenated Derivatives.

ABSTRACT: The tetracyclic pyrido[4,3-b]carbazole olivacine and four of its oxygenated derivatives have been synthesized by a late-stage palladium-catalyzed Heck-type cyclization of the pyrrole ring as a key step. In a test for the inhibition of the growth of Mycobacterium tuberculosis, 9-methoxyolivacine showed the most significant inhibitory activity against Mycobacterium tuberculosis, with an MIC₉₀ value of 1.5 μM.

SUBMITTER: Schmidt U 

PROVIDER: S-EPMC6100493 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature