Characterization of kinase gene expression and splicing profile in prostate cancer with RNA-Seq data.

ABSTRACT:

Background

Alternative splicing is a ubiquitous post-transcriptional regulation mechanism in most eukaryotic genes. Aberrant splicing isoforms and abnormal isoform ratios can contribute to cancer development. Kinase genes are key regulators of multiple cellular processes. Many kinases are found to be oncogenic and have been intensively investigated in the study of cancer and drugs. RNA-Seq provides a powerful technology for genome-wide study of alternative splicing in cancer besides the conventional gene expression profiling. But this potential has not been fully demonstrated yet.

Methods

We characterized the transcriptome profile of prostate cancer using RNA-Seq data from viewpoints of both differential expression and differential splicing, with an emphasis on kinase genes

SUBMITTER: Feng H 

PROVIDER: S-EPMC6101066 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature