High AGR2 protein is a feature of low grade endometrial cancer cells.

ABSTRACT:

Background

Biomarkers for identification of endometrial cancers (ECs) with high risk of recurrence are required to reduce the rising EC-related mortality. AGR2 is a prognostic marker in several hormonally-regulated cancers.

Aim

To assess the utility of AGR2 as a prognostic marker in EC.

Methods

AGR2 immunoexpression was evaluated in 163 human endometrial samples. Change in AGR2 mRNA levels in response to oestrogen and dihydrotestosterone was studied in vitro.

Results

Upregulation of AGR2 (protein and mRNA) was seen in low grade EC, compared to the postmenopausal endometrium (P = 0.013) and to the high-grade EC (P < 0.0001). Elevated AGR2 protein expression-scores were associated with a high expression of estrogen alpha (ERα),

SUBMITTER: Kamal A 

PROVIDER: S-EPMC6101135 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature