Optical in vivo imaging detection of preclinical models of gut tumors through the expression of integrin αVβ3.

ABSTRACT: Optical imaging and Fluorescent Molecular Tomography (FMT) are becoming increasingly important for the study of different preclinical models of cancer, providing a non-invasive method for the evaluation of tumor progression in a relatively simple and fast way. Intestinal tumors, in particular colorectal cancer (CRC), represent a major cause of cancer-related death in Western countries: despite the presence of a number of preclinical models of intestinal carcinogenesis, there is a paucity of information about the possibility to detect intestinal tumors using fluorescent probes and optical in vivo imaging. Herein, we identify the detection of integrin αvβ3 by FMT and optical imaging as an effective approach to assess the occurrence and progression of intestinal carcinogenesis in genet

SUBMITTER: Marelli G 

PROVIDER: S-EPMC6101137 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature