Combination of electroporation delivered metabolic modulators with low-dose chemotherapy in osteosarcoma.

ABSTRACT:

Background

Osteosarcoma accounts for roughly 60% of all malignant bone tumors in children and young adults. The five-year survival rate for localized tumors after surgery and chemotherapy is approximately 70% whilst it drastically reduces to 15-30% in metastatic cases. Metabolic modulation is known to increase sensitivity of cancers to chemotherapy. A novel treatment strategy in Osteosarcoma is needed to battle this devastating malady.

Results

Electroporation-delivered metabolic modulators were more effective in halting the cell cycle of Osteosarcoma cells and this negatively affects their ability to recover and proliferate, as shown in colony formation assays. Electroporation-delivered metabolic modulators increase the sensitivity of Osteosarcoma cells to chemotherapy and t

SUBMITTER: Gill KS 

PROVIDER: S-EPMC6101145 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature