A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function.

ABSTRACT: Azobenzene photoresponsive elements can be installed on sulfonylureas, yielding optical control over pancreatic beta cell function and insulin release. An obstacle to such photopharmacological approaches remains the use of ultraviolet-blue illumination. Herein, we synthesize and test a novel yellow light-activated sulfonylurea based on a heterocyclic azobenzene bearing a push-pull system.

SUBMITTER: Broichhagen J 

PROVIDER: S-EPMC6101206 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature