Development and Functional Characterization of Murine Tolerogenic Dendritic Cells.

ABSTRACT: The immune system operates by maintaining a tight balance between coordinating responses against foreign antigens and maintaining an unresponsive state against self-antigens as well as antigens derived from commensal organisms. The disruption of this immune homeostasis can lead to chronic inflammation and to the development of autoimmunity. Dendritic cells (DCs) are the professional antigen-presenting cells of the innate immune system involved in activating naïve T cells to initiate immune responses against foreign antigens. However, DCs can also be differentiated into TolDCs that act to maintain and promote T cell tolerance and to suppress effector cells contributing to the development of either autoimmune or chronic inflammation conditions. The recent advancement in our understanding of

SUBMITTER: Wei HJ 

PROVIDER: S-EPMC6101271 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature