Periostin is a negative prognostic factor and promotes cancer cell proliferation in non-small cell lung cancer.

ABSTRACT: Periostin is a matricellular protein that is secreted by fibroblasts and interacts with various cell-surface integrin molecules. Although periostin is known to support tumor development in human malignancies, little is known about its effect on lung-cancer progression. We here demonstrate that periostin is a negative prognostic factor that increases tumor proliferation through ERK signaling in non-small cell lung carcinoma. We classified 189 clinical specimens from patients with non-small cell lung-cancer according to high or low periostin expression, and found a better prognosis for patients with low rather than high periostin, even in cases of advanced-stage cancer. In a syngenic implantation model, murine Ex3LL lung-cancer cells formed smaller tumor nodules in periostin^-/- mi

SUBMITTER: Okazaki T 

PROVIDER: S-EPMC6101292 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature