Heterochromatin and RNAi regulate centromeres by protecting CENP-A from ubiquitin-mediated degradation.

ABSTRACT: Centromere is a specialized chromatin domain that plays a vital role in chromosome segregation. In most eukaryotes, centromere is surrounded by the epigenetically distinct heterochromatin domain. Heterochromatin has been shown to contribute to centromere function, but the precise role of heterochromatin in centromere specification remains elusive. Centromeres in most eukaryotes, including fission yeast (Schizosaccharomyces pombe), are defined epigenetically by the histone H3 (H3) variant CENP-A. In contrast, the budding yeast Saccharomyces cerevisiae has genetically-defined point centromeres. The transition between regional centromeres and point centromeres is considered as one of the most dramatic evolutionary events in centromere evolution. Here we demonstrated that Cse4, the budding yea

SUBMITTER: Yang J 

PROVIDER: S-EPMC6101405 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature