Gut Microbiota and Clinical Features Distinguish Colonization With Klebsiella pneumoniae Carbapenemase-Producing Klebsiella pneumoniae at the Time of Admission to a Long-term Acute Care Hospital.

ABSTRACT:

Background

Identification of gut microbiota features associated with antibiotic-resistant bacterial colonization may reveal new infection prevention targets.

Methods

We conducted a matched, case-control study of long-term acute care hospital (LTACH) patients to identify gut microbiota and clinical features associated with colonization by Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae (KPC-Kp), an urgent antibiotic resistance threat. Fecal or rectal swab specimens were collected and tested for KPC-Kp; 16S rRNA gene-based sequencing was performed. Comparisons were made between cases and controls in calibration and validation subsamples using microbiota similarity indices, logistic regression, and unit-weighted predictive models.

Results

SUBMITTER: Seekatz AM 

PROVIDER: S-EPMC6101546 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature