MMARGE: Motif Mutation Analysis for Regulatory Genomic Elements.

ABSTRACT: Cell-specific patterns of gene expression are determined by combinatorial actions of sequence-specific transcription factors at cis-regulatory elements. Studies indicate that relatively simple combinations of lineage-determining transcription factors (LDTFs) play dominant roles in the selection of enhancers that establish cell identities and functions. LDTFs require collaborative interactions with additional transcription factors to mediate enhancer function, but the identities of these factors are often unknown. We have shown that natural genetic variation between individuals has great utility for discovering collaborative transcription factors. Here, we introduce MMARGE (Motif Mutation Analysis of Regulatory Genomic Elements), the first publicly available suite of software tools that int

SUBMITTER: Link VM 

PROVIDER: S-EPMC6101580 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature