RRR-α-Tocopherol Is the Predominant Stereoisomer of α-Tocopherol in Human Milk.

ABSTRACT:

Background

The naturally occurring α-tocopherol (α-T) stereoisomer, RRR-α-tocopherol (RRR-α-T), is known to be more bioactive than all-rac-α-tocopherol (all-rac-α-T), a synthetic racemic mixture of 8 stereoisomers. There is widespread use of all-rac-α-T in maternal supplements.

Objective

The aim of the study was to thoroughly describe the α-T stereoisomer profile of human milk.

Methods

We measured the α-T stereoisomer profile in milk from 2 cohorts of women: a cohort of 121 women who provided milk on days 30 and 60 of lactation (study 1) and a separate cohort of 51 women who provided milk on days 10, 21, 71, and 120 of lactation (study 2).

Results

RRR-α-T was the predominant stereoisomer (P < 0.0001) in all sampl

SUBMITTER: Kuchan MJ 

PROVIDER: S-EPMC6101621 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature