Intracellular Pathways Involved in Bone Regeneration Triggered by Recombinant Silk-silica Chimeras.

ABSTRACT: Biomineralization at the organic-inorganic interface is critical to many biology material functions in vitro and in vivo. Recombinant silk-silica fusion peptides are organic-inorganic hybrid material systems that can be effectively used to study and control biologically-mediated mineralization due to the genetic basis of sequence control. However, to date, the mechanisms by which these functionalized silk-silica proteins trigger the differentiation of human mesenchymal stem cells (hMSCs) to osteoblasts remain unknown. To address this challenge, we analyzed silk-silica surfaces for silica-hMSC receptor binding and activation, and the intracellular pathways involved in the induction of osteogenesis on these bioengineered biomaterials. The induction of gene expression of αVβ3 in

SUBMITTER: Martin-Moldes Z 

PROVIDER: S-EPMC6101667 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature