The regulation of normal and neoplastic hematopoiesis is dependent on microenvironmental cells.
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ABSTRACT:
SUBMITTER: Kaushansky K
PROVIDER: S-EPMC6102082 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
The regulation of normal and neoplastic hematopoiesis is dependent on microenvironmental cells.
Kaushansky Kenneth K Zhan Huichun H
Advances in biological regulation 20180627
Each day the adult human produces 4 × 10<sup>11</sup> red blood cells, 1 × 10<sup>11</sup> white blood cells and 1 × 10<sup>11</sup> platelets, levels of production which can increase 10-20 fold in times of heightened demand. Hematopoiesis, or the formation of the ten different types of blood and marrow cells, is a complex process involving hematopoietic stem cells (HSCs), cytokine growth factors and cell surface adhesion molecules, and both specific and ubiquitous transcription factors. The mar ...[more]
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