Periostin promotes liver fibrogenesis by activating lysyl oxidase in hepatic stellate cells.

ABSTRACT: Liver fibrosis arises from dysregulated wound healing due to persistent inflammatory hepatic injury. Periostin is a nonstructural extracellular matrix protein that promotes organ fibrosis in adults. Here, we sought to identify the molecular mechanisms in periostin-mediated hepatic fibrosis. Hepatic fibrosis in periostin^-/- mice was attenuated as evidenced by significantly reduced collagen fibril density and liver stiffness compared with those in WT controls. A single dose of carbon tetrachloride caused similar acute liver injury in periostin^-/- and WT littermates, and we did not detect significant differences in transaminases and major fibrosis-related hepatic gene expression between these two genotypes. Activated hepatic stellate cells (HSCs) are the ma

SUBMITTER: Kumar P 

PROVIDER: S-EPMC6102155 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature