Memory Inflation Drives Tissue-Resident Memory CD8⁺ T Cell Maintenance in the Lung After Intranasal Vaccination With Murine Cytomegalovirus.

ABSTRACT: Tissue-resident memory T (T_RM) cells provide first-line defense against invading pathogens encountered at barrier sites. In the lungs, T_RM cells protect against respiratory infections, but wane more quickly than T_RM cells in other tissues. This lack of a sustained T_RM population in the lung parenchyma explains, at least in part, why infections with some pathogens, such as influenza virus and respiratory syncytial virus (RSV), recur throughout life. Intranasal (IN) vaccination with a murine cytomegalovirus (MCMV) vector expressing the M protein of RSV (MCMV-M) has been shown to elicit robust populations of CD8⁺ T_RM cells that accumulate over time and mediate early viral clearance. To extend this finding, we compared the infla

SUBMITTER: Morabito KM 

PROVIDER: S-EPMC6102355 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature