Cancer Cells Exploit Notch Signaling to Redefine a Supportive Cytokine Milieu.

ABSTRACT: Notch signaling is a well-known key player in the communication between adjacent cells during organ development, when it controls several processes involved in cell differentiation. Notch-mediated communication may occur through the interaction of Notch receptors with ligands on adjacent cells or by a paracrine/endocrine fashion, through soluble molecules that can mediate the communication between cells at distant sites. Dysregulation of Notch pathway causes a number of disorders, including cancer. Notch hyperactivation may be caused by mutations of Notch-related genes, dysregulated upstream pathways, or microenvironment signals. Cancer cells may exploit this aberrant signaling to "educate" the surrounding microenvironment cells toward a pro-tumoral behavior. This may occur because of key

SUBMITTER: Colombo M 

PROVIDER: S-EPMC6102368 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature