A Plasmodium Cross-Stage Antigen Contributes to the Development of Experimental Cerebral Malaria.

ABSTRACT: Cerebral malaria is a complex neurological syndrome caused by an infection with Plasmodium falciparum parasites and is exclusively attributed to a series of host-parasite interactions at the pathological blood-stage of infection. In contrast, the preceding intra-hepatic phase of replication is generally considered clinically silent and thereby excluded from playing any role in the development of neurological symptoms. In this study, however, we present an antigen PbmaLS_05 that is presented to the host immune system by both pre-erythrocytic and intra-erythrocytic stages and contributes to the development of cerebral malaria in mice. Although deletion of the endogenous PbmaLS_05 prevented the development of experimental cerebral malaria (ECM) in susceptible mice after b

SUBMITTER: Fernandes P 

PROVIDER: S-EPMC6102508 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature