Effect of Hydrophobic Polypeptide Length on Performances of Thermo-Sensitive Hydrogels.

ABSTRACT: Thermosensitive gels are commonly used as drug carriers in medical fields, mainly due to their convenient processing and easy functionalization. However, their overall performance has been severely affected by their unsatisfying biocompatibility and biodegradability. To this end, we synthesized poly(l-alanine) (PLAla)-based thermosensitive hydrogels with different degrees of polymerization by ring-opening polymerization. The obtained mPEG45−PLAla copolymers showed distinct transition temperatures and degradation abilities. It was found that slight changes in the length of hydrophobic side groups had a decisive effect on the gelation behavior of the polypeptide hydrogel. Longer hydrophobic ends led to a lower gelation temperature of gel at the same concentration, which implied better gelati

SUBMITTER: Han J 

PROVIDER: S-EPMC6102579 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature