Bioinformatics approach reveals the key role of C‑X‑C motif chemokine receptor 2 in endometriosis development.

ABSTRACT: Endometriosis is a common gynecological disease, affecting 6‑10% of women of reproductive age. The precise mechanisms underlying the development of endometriosis remain unclear. In the present study, a bioinformatics approach was applied to systematically identify the pathways and genes involved in the development of endometriosis and to discover potential biomarkers. The gene expression profiles of GSE6364, a microarray dataset of endometrial biopsies obtained from women with or without endometriosis, was downloaded from the Gene Expression Omnibus DataSets database that stores original submitter‑supplied records (series, samples and platforms), as well as curated datasets. Differentially expressed gene (DEG) analysis was performed with GEO2R. DAVID was used to analyze the gene ontology e

SUBMITTER: Tan A 

PROVIDER: S-EPMC6102705 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature