PU.1 regulates Alzheimer's disease-associated genes in primary human microglia.

ABSTRACT:

Background

Microglia play critical roles in the brain during homeostasis and pathological conditions. Understanding the molecular events underpinning microglial functions and activation states will further enable us to target these cells for the treatment of neurological disorders. The transcription factor PU.1 is critical in the development of myeloid cells and a major regulator of microglial gene expression. In the brain, PU.1 is specifically expressed in microglia and recent evidence from genome-wide association studies suggests that reductions in PU.1 contribute to a delayed onset of Alzheimer's disease (AD), possibly through limiting neuroinflammatory responses.

Methods

To investigate how PU.1 contributes to immune activation in human microglia, microarray analysis was

SUBMITTER: Rustenhoven J 

PROVIDER: S-EPMC6102813 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature