Strain-transcending neutralization of malaria parasite by antibodies against Plasmodium falciparum enolase.

ABSTRACT:

Background

Plasmodium enolase is a target for the growth neutralizing antibodies. Interestingly, the three invasive stages i.e. sporozoites, merozoites, and ookinetes express this protein on their cell surface. Polyclonal anti-Plasmodium falciparum enolase (Pfeno) antibodies disrupt traversal of ookinete through mosquito mid-gut wall as well as have inhibitory effect on parasite growth at erythrocytic stage. In a recent study, it was observed that immunization with a unique epitope of parasite enolase (EWGWS) could confer partial protection against mouse malaria. Further validation is needed for the protective potential of this unique epitope in otherwise highly conserved enolase.

Methods

In order to investigate the efficacy of growth inhibitory potential of the epitope of P

SUBMITTER: Dutta S 

PROVIDER: S-EPMC6102825 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature