Impact of gram negative bacteria airway recolonization on the occurrence of chronic lung allograft dysfunction after lung transplantation in a population of cystic fibrosis patients.

ABSTRACT:

Background

Chronic Lung Allograft Dysfunction (CLAD) is the main cause of morbidity and mortality after the first year following lung transplantation (LTx). Risk factors of CLAD have been extensively studied, but the association between gram-negative bacteria (GNB) bronchial colonization and the development of CLAD is controversial. The purpose of our study was to investigate the association between post-transplant recolonization with the same species or de-novo colonization with a new GNB species and CLAD. The same analysis was performed on a sub-group of patients at the strain level using Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry technique.

Results

Forty adult cystic fibrosis (CF) patients who underwent a first bilateral LTx in the Univer

SUBMITTER: Orfanos S 

PROVIDER: S-EPMC6102836 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature