Subretinal macrophages produce classical complement activator C1q leading to the progression of focal retinal degeneration.

ABSTRACT:

Background

The role of the alternative complement pathway and its mediation by retinal microglia and macrophages, is well-established in the pathogenesis of Age-Related Macular Degeneration (AMD). However, the contribution of the classical complement pathway towards the progression of retinal degenerations is not fully understood, including the role of complement component 1q (C1q) as a critical activator molecule of the classical pathway. Here, we investigated the contribution of C1q to progressive photoreceptor loss and neuroinflammation in retinal degenerations.

Methods

Wild-type (WT), C1qa knockout (C1qa^-/-) and mice treated with a C1q inhibitor (ANX-M1; Annexon Biosciences), were exposed to photo-oxidative damage (PD) and were observed for progressive lesion

SUBMITTER: Jiao H 

PROVIDER: S-EPMC6102844 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature