Bacterial Methionine Metabolism Genes Influence Drosophila melanogaster Starvation Resistance.

ABSTRACT: Animal-associated microorganisms (microbiota) dramatically influence the nutritional and physiological traits of their hosts. To expand our understanding of such influences, we predicted bacterial genes that influence a quantitative animal trait by a comparative genomic approach, and we extended these predictions via mutant analysis. We focused on Drosophila melanogaster starvation resistance (SR). We first confirmed that D. melanogaster SR responds to the microbiota by demonstrating that bacterium-free flies have greater SR than flies bearing a standard 5-species microbial community, and we extended this analysis by revealing the species-specific influences of 38 genome-sequenced bacterial species on D. melanogaster SR. A subsequent metagenome-wide association analysi

SUBMITTER: Judd AM 

PROVIDER: S-EPMC6102978 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature