Voxel-based morphometry multi-center mega-analysis of brain structure in social anxiety disorder.

ABSTRACT: Social anxiety disorder (SAD) is a prevalent and disabling mental disorder, associated with significant psychiatric co-morbidity. Previous research on structural brain alterations associated with SAD has yielded inconsistent results concerning the direction of the changes in gray matter (GM) in various brain regions, as well as on the relationship between brain structure and SAD-symptomatology. These heterogeneous findings are possibly due to limited sample sizes. Multi-site imaging offers new opportunities to investigate SAD-related alterations in brain structure in larger samples. An international multi-center mega-analysis on the largest database of SAD structural T1-weighted 3T MRI scans to date was performed to compare GM volume of SAD-patients (n = 174) and healthy control (HC)-parti

SUBMITTER: Bas-Hoogendam JM 

PROVIDER: S-EPMC6103329 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature