Complement receptor 1 (CR1, CD35) association with susceptibility to leprosy.

ABSTRACT:

Background

Pathophysiological mechanisms are still incompletely understood for leprosy, an urgent public health issue in Brazil. Complement receptor 1 (CR1) binds complement fragments C3b/C4b deposited on mycobacteria, mediating its entrance in macrophages. We investigated CR1 polymorphisms, gene expression and soluble CR1 levels in a case-control study with Brazilian leprosy patients, aiming to understand the role of this receptor in differential susceptibility to the disease.

Methodology

Nine polymorphisms were haplotyped by multiplex PCR-SSP in 213 leprosy patients (47% multibacillary) and 297 controls. mRNA levels were measured by qPCR and sCR1 by ELISA, in up to 80 samples.

Principal findings

Individuals with the most common recombinant haplotype harboring rs3849

SUBMITTER: Kretzschmar GC 

PROVIDER: S-EPMC6103516 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature