Peritumoral monocytes induce cancer cell autophagy to facilitate the progression of human hepatocellular carcinoma.

ABSTRACT: Macroautophagy/autophagy is an important catabolic process mediating cellular homeostasis and plays critical roles in cancer development. Whereas autophagy has been widely studied in various pathological models, little is known about the distribution, clinical significance and regulatory mechanism of this process in human hepatocellular carcinoma (HCC). In the present study, we found that tumor tissues exhibited significantly increased levels of autophagy compared with non-tumor tissues, and cancer cells with higher levels of autophagy were predominantly enriched in the invading edge regions of human HCC. Increased MAP1LC3B/LC3B expression in the invading edge regions was significantly correlated with a higher density of closely located monocytes, and TNF and IL1B derived from tumor-activa

SUBMITTER: Chen DP 

PROVIDER: S-EPMC6103724 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature