Estrogenic-dependent glutamatergic neurotransmission from kisspeptin neurons governs feeding circuits in females.

ABSTRACT: The neuropeptides tachykinin2 (Tac2) and kisspeptin (Kiss1) in hypothalamic arcuate nucleus Kiss1 (Kiss1^ARH) neurons are essential for pulsatile release of GnRH and reproduction. Since 17β-estradiol (E2) decreases Kiss1 and Tac2 mRNA expression in Kiss1^ARH neurons, the role of Kiss1^ARH neurons during E2-driven anorexigenic states and their coordination of POMC and NPY/AgRP feeding circuits have been largely ignored. Presently, we show that E2 augmented the excitability of Kiss1^ARH neurons by amplifying Cacna1g, Hcn1 and Hcn2 mRNA expression and T-type calcium and h-currents. E2 increased Slc17a6 mRNA expression and glutamatergic synaptic input to arcuate neurons, which excited POMC and inhibited NPY/AgRP neurons via metabotro

SUBMITTER: Qiu J 

PROVIDER: S-EPMC6103748 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature