Id3 Restricts γδ NKT Cell Expansion by Controlling Egr2 and c-Myc Activity.

ABSTRACT: γδ NKT cells are neonatal-derived γδ T lymphocytes that are grouped together with invariant NKT cells based on their shared innate-like developmental program characterized by the transcription factor PLZF (promyelocytic leukemia zinc finger). Previous studies have demonstrated that the population size of γδ NKT cells is tightly controlled by Id3-mediated inhibition of E-protein activity in mice. However, how E proteins promote γδ NKT cell development and expansion remains to be determined. In this study, we report that the transcription factor Egr2, which also activates PLZF expression in invariant NKT cells, is essential for regulating γδ NKT cell expansion. We observed a higher expression of Egr family genes in γδ NKT cells compared with the conventional γδ T cell population. Loss of fun

SUBMITTER: Zhang B 

PROVIDER: S-EPMC6103809 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature