Deciphering the oviductal extracellular vesicles content across the estrous cycle: implications for the gametes-oviduct interactions and the environment of the potential embryo.

ABSTRACT:

Background

The success of early reproductive events depends on an appropriate communication between gametes/embryos and the oviduct. Extracellular vesicles (EVs) contained in oviductal secretions have been suggested as new players in mediating this crucial cross-talk by transferring their cargo (proteins, mRNA and small ncRNA) from cell to cell. However, little is known about the oviductal EVs (oEVS) composition and their implications in the reproductive success. The aim of the study was to determine the oEVs content at protein, mRNA and small RNA level and to examine whether the oEVs content is under the hormonal influence of the estrous cycle.

Results

We identified the presence of oEVs, exosomes and microvesicles, in the bovine oviductal fluid at different stages of the es

SUBMITTER: Alminana C 

PROVIDER: S-EPMC6103977 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature