Seasonality and heterogeneity of malaria transmission determine success of interventions in high-endemic settings: a modeling study.

ABSTRACT:

Background

Malaria transmission is both seasonal and heterogeneous, and mathematical models that seek to predict the effects of possible intervention strategies should accurately capture realistic seasonality of vector abundance, seasonal dynamics of within-host effects, and heterogeneity of exposure, which may also vary seasonally.

Methods

Prevalence, incidence, asexual parasite and gametocyte densities, and infectiousness measurements from eight study sites in sub-Saharan Africa were used to calibrate an individual-based model with innate and adaptive immunity. Data from the Garki Project was used to fit exposure rates and parasite densities with month-resolution. A model capturing Garki seasonality and seasonal heterogeneity of exposure was used as a framework for charact

SUBMITTER: Selvaraj P 

PROVIDER: S-EPMC6104018 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature