A human RNA polymerase II subunit is encoded by a recently generated multigene family.

ABSTRACT:

Background

The sequences encoding the yeast RNA polymerase II (RPB) subunits are single copy genes.

Results

While those characterized so far for the human (h) RPB are also unique, we show that hRPB subunit 11 (hRPB11) is encoded by a multigene family, mapping on chromosome 7 at loci p12, q11.23 and q22. We focused on two members of this family, hRPB11a and hRPB11b: the first encodes subunit hRPB11a, which represents the major RPB11 component of the mammalian RPB complex; the second generates polypeptides hRPB11balpha and hRPB11bbeta through differential splicing of its transcript and shares homologies with components of the hPMS2L multigene family related to genes involved in mismatch-repair functions (MMR). Both hRPB11a and b genes are transcribed in all human tissues teste

SUBMITTER: Grandemange S 

PROVIDER: S-EPMC61041 | biostudies-literature | 2001

REPOSITORIES: biostudies-literature