Aspiration pneumonia induces muscle atrophy in the respiratory, skeletal, and swallowing systems.

ABSTRACT:

Background

Repetition of the onset of aspiration pneumonia in aged patients is common and causes chronic inflammation. The inflammation induces proinflammatory cytokine production and atrophy in the muscles. The proinflammatory cytokines induce muscle proteolysis by activating calpains and caspase-3, followed by further degradation by the ubiquitin-proteasome system. Autophagy is another pathway of muscle atrophy. However, little is known about the relationship between aspiration pneumonia and muscle. For swallowing muscles, it is not clear whether they produce cytokines. The main objective of this study was to determine whether aspiration pneumonia induces muscle atrophy in the respiratory (the diaphragm), skeletal (the tibialis anterior, TA), and swallowing (the tongue) systems,

SUBMITTER: Komatsu R 

PROVIDER: S-EPMC6104110 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature