MiRNA-23a/27a attenuates muscle atrophy and renal fibrosis through muscle-kidney crosstalk.

ABSTRACT:

Background

The treatment of muscle wasting is accompanied by benefits in other organs, possibly resulting from muscle-organ crosstalk. However, how the muscle communicates with these organs is less understood. Two microRNAs (miRs), miR-23a and miR-27a, are located together in a gene cluster and regulate proteins that are involved in the atrophy process. MiR-23a/27a has been shown to reduce muscle wasting and act as an anti-fibrotic agent. We hypothesized that intramuscular injection of miR-23a/27a would counteract both muscle wasting and renal fibrosis lesions in a streptozotocin-induced diabetic model.

Methods

We generated an adeno-associated virus (AAV) that overexpresses the miR-23a∼27a∼24-2 precursor RNA and injected it into the tibialis anterior muscle of streptozotocin

SUBMITTER: Zhang A 

PROVIDER: S-EPMC6104113 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature