A General Overview on Non-coding RNA-Based Diagnostic and Therapeutic Approaches for Liver Diseases.

ABSTRACT: Liver diseases contribute to the global mortality and morbidity and still represent a major health problem leading to the death of people worldwide. Although there are several treatment options available for Hepatitis C infections, for most liver disease the pharmacological options are still limited. Therefore, the development of new targets against liver diseases is of high interest. Non-coding RNA (ncRNA) such as microRNA (miRNA) or long ncRNA (lncRNA) have been shown to be deeply involved in the pathophysiology of almost all acute and chronic liver diseases. The emerging evidence showed the potential therapeutic use of miRNA associated with different steps of hepatic pathophysiology. In the present review, we summarize emerging insights of ncRNA in liver diseases. We also highlight exam

SUBMITTER: Roy S 

PROVIDER: S-EPMC6104154 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature