Gene Expression Differences in Pediatric Lymphatic Malformations: Size Really Matters.

ABSTRACT: Lymphatic malformations (LMs) are congenital vascular anomalies characterized by dilated and cystic lymphatic channels. They are subdivided into macrocystic and microcystic lesions based upon the predominant size of the cysts involved. However, significant differences in clinical characteristics, treatment outcomes, and prognosis between macrocytic and microcytic disease suggest variation in underlying biologic and genetic influences. Indirect differential expression analysis revealed that 426 genes are significantly different (p < 0.01) in a small sample of LM subtypes. Functional analyses on the differentially expressed gene sets showed that microcystic LM gene expression favors a prooncogenic profile with upregulation of MYC target genes and cell cycle proteins, whereas macrocystic expr

SUBMITTER: Gomez-Acevedo H 

PROVIDER: S-EPMC6104254 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature