Estrogen Treatment Reverses Prematurity-Induced Disruption in Cortical Interneuron Population.

ABSTRACT: Development of cortical interneurons continues until the end of human pregnancy. Premature birth deprives the newborns from the supply of maternal estrogen and a secure intrauterine environment. Indeed, preterm infants suffer from neurobehavioral disorders. This can result from both preterm birth and associated postnatal complications, which might disrupt recruitment and maturation of cortical interneurons. We hypothesized that interneuron subtypes, including parvalbumin-positive (PV⁺), somatostatin-positive (SST⁺), calretinin-positive (CalR⁺), and neuropeptide Y-positive (NPY⁺) interneurons, were recruited in the upper and lower cortical layers in a distinct manner with advancing gestational age. In addition, preterm birth would disrupt the hete

SUBMITTER: Panda S 

PROVIDER: S-EPMC6104301 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature