Cyclic Lipodepsipeptides From Pseudomonas spp. - Biological Swiss-Army Knives.

ABSTRACT: Cyclic lipodepsipeptides produced by Pseudomonas spp. (Ps-CLPs) are biosurfactants that constitute a diverse class of versatile bioactive natural compounds with promising application potential. While chemically diverse, they obey a common structural blue-print, allowing the definition of 14 distinct groups with multiple structurally homologous members. In addition to antibacterial and antifungal properties the reported activity profile of Ps-CLPs includes their effect on bacterial motility, biofilm formation, induced defense responses in plants, their insecticidal activity and anti-proliferation effects on human cancer cell-lines. To further validate their status of potential bioactive substances, we assessed the results of 775 biological tests on 51 Ps-CLPs available from literatur

SUBMITTER: Geudens N 

PROVIDER: S-EPMC6104475 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature