Organizing combinatorial transcription factor recruitment at cis-regulatory modules.
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ABSTRACT:
SUBMITTER: Dubois-Chevalier J
PROVIDER: S-EPMC6104691 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Organizing combinatorial transcription factor recruitment at cis-regulatory modules.
Dubois-Chevalier Julie J Mazrooei Parisa P Lupien Mathieu M Staels Bart B Lefebvre Philippe P Eeckhoute Jérôme J
Transcription 20171128 4
Gene transcriptional regulation relies on cis-regulatory DNA modules (CRMs), which serve as nexus sites for integration of multiple transcription factor (TF) activities. Here, we provide evidence and discuss recent literature indicating that TF recruitment to CRMs is organized into combinations of trans-regulatory protein modules (TRMs). We propose that TRMs are functional entities composed of TFs displaying the most highly interdependent chromatin binding which are, in addition, able to modulat ...[more]
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