Effects of reproductive period duration and number of pregnancies on midlife ECG indices: a secondary analysis from the Women's Health Initiative Clinical Trial.

ABSTRACT:

Objectives

Pregnancy, menses and menopause are related to fluctuations in endogenous sex hormones in women, which cumulatively may alter cardiac electrical conduction. Therefore, we sought to study the association between number of pregnancies and reproductive period duration (RD, time from menarche to menopause) with ECG intervals in the Women's Health Initiative Clinical Trials.

Design

Secondary analysis of multicentre clinical trial.

Setting

USA.

Primary outcome measures

ECGintervals: PR interval, P-wave duration, P-wave dispersion, QTc interval.

Participants

n=40 687 women (mean age=62 years) participating in the Women's Health Initiative Clinical Trials. 82.5% were white, 9.3% black, 4% Hispanic and 2.7% Asian.

Methods

In primary analysis, we

SUBMITTER: Parikh NI 

PROVIDER: S-EPMC6104755 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature