Is elevation of N-terminal pro-B-type natriuretic peptide at discharge associated with 2-year composite endpoint of all-cause mortality and heart failure hospitalisation after transcatheter aortic valve implantation? Insights from a multicentre prospective OCEAN-TAVI registry in Japan.

ABSTRACT:

Objectives

The aim of this study was to investigate the 2-year prognostic impact of N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels at discharge following transcatheter aortic valve implantation (TAVI).

Design

Multicentre prospective observational study.

Settings

Seven institutions from multicentre, observational registry of symptomatic patients with severe aortic stenosis who undergo TAVI.

Participants

We enrolled 500 consecutive patients who underwent TAVI with measurements of NT-proBNP at discharge between 2013 and 2016. Study patients were stratified into two groups according to survival classification and regression tree (CART) analysis: high versus low NT-proBNP groups.

Interventions

The impact of high NT-proBNP on a 2-year composite e

SUBMITTER: Mizutani K 

PROVIDER: S-EPMC6104765 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature