Risk Factors for Indeterminate Outcome on Interferon Gamma Release Assay in Non-US-Born Persons Screened for Latent Tuberculosis Infection.

ABSTRACT:

Background

Non-US-born individuals account for the majority of active tuberculosis (TB) in the United States. Interferon gamma release assay (IGRA) is the preferred diagnostic test for latent TB but can produce an indeterminate result. We investigated the prevalence and predictors of an indeterminate IGRA (IND-IGRA) in a diverse cohort of non-US-born individuals and evaluated outcomes after IND-IGRA.

Methods

We identified patient age ≥18 years who had an outpatient IGRA between 2010 and 2017 in our health system and whose primary language was not English. We used univariate and multivariable logistic regression to examine the association of IND-IGRA with a variety of clinical factors.

Results

Of 3128 outpatients with ≥1 IGRA done, 33% were Asian, 30% Hispanic, and 29%

SUBMITTER: Sharninghausen JC 

PROVIDER: S-EPMC6104778 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature