Development of a population pharmacokinetic model of olanzapine for Chinese health volunteers and patients with schizophrenia.

ABSTRACT:

Objective

Olanzapine is an atypical antipsychotic drug commonly used for the treatment of schizophrenia. However, there are still many complications associated with the use of olanzapine, and researchers continually strive to improve the handling of data from regular therapeutic drug monitoring (TDM). The objective of this study is to optimise the individualised treatment of olanzapine by establishing a population pharmacokinetics (PopPK) model in Chinese patients with schizophrenia.

Methods

This study integrates an extensive collection of concentration data from healthy volunteers after a single dose and a less extensive collection of samples from patients undergoing TDM. A PopPK model was developed using non-linear mixed-effects modelling. Potential covariates, including t

SUBMITTER: Li A 

PROVIDER: S-EPMC6104801 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature